Hydrochloric Acid → HCID 11298899、化合物

HRID 458130ノート

反応式

HRID 458130 の反応式
[C:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([N+:13]([O-])=O)[CH:4]=1)#[N:2].[H][H].[ClH:18]>O.[OH-].[Pd+2].[OH-]>[Cl-:18].[NH2:13][C:5]1[CH:4]=[C:3]([CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])[CH2:1][NH3+:2]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 11356202Methyl 4-cyano-2-nitrobenzoateHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 11298899HCID 11298899、化合物

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 962Water溶媒

実験手順

18.5 g (0.09 mol) of methyl 4-cyano-2-nitrobenzoate and 0.93 g of palladium hydroxide (20% on charcoal) are suspended in a mixture of 8 ml of concentrated hydrochloric acid (30% strength) and 315 ml of water in a Hastelloy stirred autoclave. Then, the mixture is hydrogenated at a hydrogen pressure of 17 bar until the hydrogen uptake is complete. After the pressure in the autoclave has been released and the catalyst filtered off, the filtrate is evaporated completely. This gives 19.5 g (97% strength) of 3-amino-4-methoxycarbonylbenzylammonium chloride of melting point 200–205° C.

後処理

  1. filtrationthe catalyst filtered off
  2. customthe filtrate is evaporated completely

出典と根拠

ORDレコード
ord-f545a9bf5ce34847812983b2363c5573
出典データセット
uspto-grants-2007_03
特許番号
US07189848B2

反応ノート

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