Potassium Carbonate → Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

HRID 458160

反応式

HRID 458160 の反応式
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].C(=O)([O-])[O-].[K+].[K+].Cl[C@H:18]([CH3:23])[C:19]([O:21][CH3:22])=[O:20]>[Cl-].C([N+](CCCCCC)(CCCCCC)CCCCCC)CCCCC>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][C@@H:18]([CH3:23])[C:19]([O:21][CH3:22])=[O:20]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 774682,3,4-TrifluoroanilineHCID 149593Methyl 2-chloropropanoate, (R)-

生成物 1

HCID 10125210Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

試薬・触媒・溶媒 1

HCID 80021Tetrahexylammonium chloride触媒

実験手順

In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-chloropropionate (92 mg) and tetrahexylammonium chloride (40 mg). As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 56 mg (36%) of the title compound.

後処理

  1. customIn accordance with the process of Example 2, a condensation reaction

出典と根拠

ORDレコード
ord-fa10b7da2f6c432c96677422272918ed
出典データセット
uspto-grants-2007_03
特許番号
US07189847B2

関連ノート

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