反応式
C([O:3][C:4]([C:6]1[S:10][C:9]([NH:11][O:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[N:8][C:7]=1[CH3:20])=[O:5])C.[OH-].[K+].Cl>O1CCCC1CCO>[C:16]([O:15][C:13]([O:12][NH:11][C:9]1[S:10][C:6]([C:4]([OH:5])=[O:3])=[C:7]([CH3:20])[N:8]=1)=[O:14])([CH3:19])([CH3:17])[CH3:18]参加物
5
反応条件
- 温度
- 55 °C
実験手順
A stirred solution of ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate (10 g, 34.95 mmol) in tetrahydrofuran-ethanol (250 mL, 2:3) was treated with a 6N KOH solution (250 mL). The mixture was heated to 55° C. overnight. The solution was cooled to 0° C. and acidified with concd. HCl to pH 1. The solvent was evaporated in vacuo. The residue was washed with water, diethyl ether, dried in vacuo over anhydrous phosphorous pentoxide to obtain the title acid (6 g, 89%) as a white solid.
後処理
- temperatureThe solution was cooled to 0° C.
- customThe solvent was evaporated in vacuo
- washThe residue was washed with water, diethyl ether
- dry with materialdried in vacuo over anhydrous phosphorous pentoxide
- customto obtain the title acid (6 g, 89%) as a white solid
出典と根拠
- ORDレコード
- ord-26345d7f07bf4078993b2a1d11025717
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07189854B2
関連ノート
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