化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 2-(2,5-Bis-phenylethynylphenyl)-5-(4-octyloxyphenyl)-[1,3,4]oxadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Phenylacetylene | HCID 10821 | — |
| 反応物 | 1,3,4-Oxadiazole | HCID 97428 | — |
| 反応物 | Methylenechloride Hexane | HCID 21226440 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 生成物 | 2-(2,5-Bis-phenylethynylphenyl)-5-(4-octyloxyphenyl)-[1,3,4]oxadiazole | HCID 58820758 | 72% |
反応手順
Pd(PPh3)4 (71.6 mg, 0.1 mmol) and CuI (23.6 mg, 0.1 mmol) were added to a mixture of 2,(2,5-dibromophenyl)-5-[4-octyloxy)phenyl]-1,3,4-oxadiazole (3.20 g, 6.3 mmol) and phenyl acetylene (1.29 g, 12.6 mmol) in 20 mL of dry Et3N. The reaction mixture was magnetically stirred for 3 h under reflux. The cooled reaction mixture was poured into an excess amount of methanol and the precipitate was collected by filtration. Re-crystallization from methylene chloride/hexane gave 2-(2,5-bis-phenylethynylphenyl)-5-(4-octyloxyphenyl)-[1,3,4]oxadiazole (2.50 g, 72% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07192657B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-340e44f6bf814d0e96218d1447b0f382 |
| 出典メモ | uspto-grants-2007_03 |