Benzyl Chloride → Pyridinium, 4-methyl-1-(phenylmethyl)-, chloride (1:1)
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[CH2:8]([Cl:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CC(C)=O>[Cl-:15].[CH2:8]([N+:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a stirred solution of 4-methylpyridine (26 mL/0.268 mol) in 70 mL of acetone was added 31 mL (0.268 mol) of benzylchloride. The resulting mixture was stirred at 50° C. for 18 hours. After cooling to room temperature, the reaction was filtered, washed with acetone and dried under reduced pressure affording 38 g of the title compound. The filtrate was concentrated under reduced pressure producing an additional 5.6 grams of the title compound (74% combined yield). LRMS: 184.
後処理
- temperatureAfter cooling to room temperature
- filtrationthe reaction was filtered
- washwashed with acetone
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-1cc7dfa4d75e4aee8d65a11d7b84519d
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07192963B2
反応ノート
読み込み中…