Hydrochloric Acid → 5-[(Methoxycarbonyl)amino]pentanoic acid
反応式
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].C(=O)([O-])[O-].[K+].[K+].Cl[C:17]([O:19][CH2:20]C)=[O:18].Cl>O.O1CCOCC1>[CH3:20][O:19][C:17]([NH:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8])=[O:18]参加物
7
反応条件
- 温度
- 0 °C
実験手順
5-aminopentanoic acid hydrochloride (1 g, 6.5 mmol), and potassium carbonate (6.5 g, 47 mmol) were dissolved in water (15 ml) and dioxane (5 ml) then cooled to 0° C. Ethyl chloroformate (3 ml, 31.5 mmol) was added over 30 seconds, then the mixture was stirred for 4 hours at 0° C. Conc. HCl was added until acidic then the mixture was diluted with water and extracted with ether. The organic layer was dried over magnesium sulfate, evaporated and dried in vacuo to give 5-[(methoxycarbonyl)amino]pentanoic acid as a white powder (1.07 g).
後処理
- extractionextracted with ether
- dry with materialThe organic layer was dried over magnesium sulfate
- customevaporated
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-5bee31f65f5c435a90e4283a8a234e45
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07192974B2
反応ノート
読み込み中…
