3-Hydroxy-N-phenylaniline → (2s)-2-Methoxy-3-{4-[5-(3-phenylamino-phenoxy)-pent-1-ynyl]-phenyl}-propionic acid

HRID 459098

反応式

HRID 459098 の反応式
C([O:3][C:4](=[O:21])[CH:5]([O:19][CH3:20])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15][CH2:16][CH2:17]Br)=[CH:9][CH:8]=1)C.[CH:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([OH:35])[CH:30]=2)=[CH:24][CH:23]=1>>[CH3:20][O:19][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]#[C:14][CH2:15][CH2:16][CH2:17][O:35][C:31]2[CH:32]=[CH:33][CH:34]=[C:29]([NH:28][C:25]3[CH:24]=[CH:23][CH:22]=[CH:27][CH:26]=3)[CH:30]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:21]

参加物

3

反応物 2

HCID 75463-Hydroxy-N-phenylanilineHCID 694219733-[4-(5-Bromo-pent-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester

生成物 1

HCID 59015146(2s)-2-Methoxy-3-{4-[5-(3-phenylamino-phenoxy)-pent-1-ynyl]-phenyl}-propionic acid

実験手順

The title compound was prepared from 3-[4-(5-Bromo-pent-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 24 Step A and 3-hydroxydiphenylamine in a manner analogous to that described for Example 24, Step B. MS(ES) for C27H27NO4[M+H]+:430.2.

出典と根拠

ORDレコード
ord-92b2bc762cc142678fab7bee0b5c8e35
出典データセット
uspto-grants-2007_03
特許番号
US07192982B2

関連ノート

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