Butanal → HCID 178448788、化合物

HRID 45935

反応式

HRID 45935 の反応式
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[NH:3][CH:2]=1.[CH:11](=O)[CH2:12][CH2:13][CH3:14].[BH4-].[Na+]>>[CH2:11]([NH:10][C:8]1[CH:7]=[CH:6][C:5]2[NH:1][CH:2]=[N:3][C:4]=2[CH:9]=1)[CH2:12][CH2:13][CH3:14]

参加物

4

反応物 3

HCID 261ButanalHCID 136235-AminobenzimidazoleHCID 4311764Sodium borohydride

生成物 1

HCID 178448788HCID 178448788、化合物

実験手順

The compound was synthesized starting from benzimidazol-5-amine (399 mg; 3 mmol; 1 eq.), n-butanal (238 mg; 0.291 ml; 3.3 mmol; 1.1 eq.) and NaBH4 (228 mg; 6 mmol; 2 eq.) as described in method 3; Yield: 0.311 (54.9%); MS m/z: 190.4 [M+H]+; 1H-NMR (400 MHz, DMSO d6): δ 0.91 (t, 3H, 3J=7.5 Hz); 1.35-1.44 (m, 2H); 1.52-1.59 (m, 2H); 2.99 (t, 2H, 3J=7.1 Hz); 5.27 (br s, 1H); 6.53-6.55 (m, 2H); 7.25-7.27 (m, 1H); 7.84 (s, 1H); 11.83 (br s, 1H); HPLC (METHOD [A]): rt 7.51 min (95.9%)

後処理

  1. customThe compound was synthesized
  2. customrt 7.51 min (95.9%)

出典と根拠

ORDレコード
ord-306e1276847348299c142ea9dc29a27d
出典データセット
uspto-grants-2013_09
特許番号
US08541596B2

関連ノート

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