7-Hydroxyflavone → (2S)-2-methoxy-3-{4-[2-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-ethoxy]-phenyl}-propionic acid

HRID 459380

反応式

HRID 459380 の反応式
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15]Br)=[CH:9][CH:8]=1)C.[OH:20][C:21]1[CH:30]=[C:29]2[C:24]([C:25](=[O:37])[CH:26]=[C:27]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[O:28]2)=[CH:23][CH:22]=1.CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH3:18][O:17][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][O:20][C:21]2[CH:30]=[C:29]3[C:24]([C:25](=[O:37])[CH:26]=[C:27]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[O:28]3)=[CH:23][CH:22]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:19]

参加物

4

反応物 3

HCID 52818947-HydroxyflavoneHCID 58822865(2S)-3-[4-(2-bromo-ethoxy)-phenyl]2-methoxy-propionic acid ethyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

生成物 1

HCID 58822724(2S)-2-methoxy-3-{4-[2-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-ethoxy]-phenyl}-propionic acid

実験手順

The title compound was prepared from (2S)-3-[4-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 283, Step 2) and 7-hydroxy-2-phenyl-chromen-4-one via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a yellow solid.

後処理

  1. customto produce a yellow solid

出典と根拠

ORDレコード
ord-7cf6778a5b3d477caaf417a3e86ae370
出典データセット
uspto-grants-2007_03
特許番号
US07192982B2

関連ノート

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