tert-Butyl [(1S,2R)-2-azidocyclohexyl]carbamate → (1S,2R)-Cyclohexane-1,2-diamine, N1-BOC protected

HRID 459471

反応式

HRID 459471 の反応式
[N:1]([C@@H:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C@@H:5]1[NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[N+]=[N-]>CO.[Pd]>[C:14]([O:13][C:11]([NH:10][C@H:5]1[CH2:6][CH2:7][CH2:8][CH2:9][C@H:4]1[NH2:1])=[O:12])([CH3:17])([CH3:15])[CH3:16]

参加物

4

反応物 1

HCID 57416183tert-Butyl [(1S,2R)-2-azidocyclohexyl]carbamate

生成物 1

HCID 1514389(1S,2R)-Cyclohexane-1,2-diamine, N1-BOC protected収率 93.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

(1R,2S)-1-Azido-2-(tert-butoxycarbonylamino)-cyclohexane (174 mg) was dissolved in methanol (10 ml), and to the solution 10% palladium on carbon (120 mg) was added to conduct catalytic reduction under atmospheric pressure. The catalyst was separated by filtration, and the filtrate was concentrated to obtain a crude title compound (145 mg) as a colorless amorphous substance. This compound was used in the next reaction without purifying it.

後処理

  1. customThe catalyst was separated by filtration
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-ae2f5fdfeeac422ab47666376c9e13f7
出典データセット
uspto-grants-2007_03
特許番号
US07192968B2

関連ノート

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