(+/-)-cis-N1-Benzyl-N2-tert-butoxycarbonyl-N1-methyl-1,2-cyclohexanediamine → (+/-)-cis-N1-tert-Butoxycarbonyl-N2-methyl-1,2-cyclohexane-diamine

HRID 459476ノート

反応式

HRID 459476 の反応式
[CH2:1]([N:8](C)[C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])C1C=CC=CC=1.[H][H]>[Pd].CO>[C:19]([O:18][C:16]([NH:15][C@@H:10]1[CH2:11][CH2:12][CH2:13][CH2:14][C@@H:9]1[NH:8][CH3:1])=[O:17])([CH3:22])([CH3:21])[CH3:20]

参加物

5

反応物 2

HCID 58822120(+/-)-cis-N1-Benzyl-N2-tert-butoxycarbonyl-N1-methyl-1,2-cyclohexanediamineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 68907343(+/-)-cis-N1-tert-Butoxycarbonyl-N2-methyl-1,2-cyclohexane-diamine収率 92.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

(±)-cis-N1-Benzyl-N2-tert-butoxycarbonyl-N1-methyl-1,2-cyclohexanediamine (1.92 g) was added to methanol (50 ml), 10% palladium on carbon (containing 50% of water, 900 mg) was added, and the mixture was stirred for 20 hours in a hydrogen atmosphere. After separating the catalyst by filtration, the filtrate was concentrated to obtain the title compound (1.27 g) as a colorless oil.

後処理

  1. additionwas added
  2. customAfter separating the catalyst
  3. filtrationby filtration
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-8e58d1fcb86b41feb9294849ba818d6a
出典データセット
uspto-grants-2007_03
特許番号
US07192968B2

反応ノート

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