Water → 1,1-Dimethylethyl 4-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1-piperazinecarboxylate

HRID 459831ノート

反応式

HRID 459831 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[CH:16]=[CH:17][N:18]=[CH:19]3)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].B.O>O1CCCC1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[CH2:16][CH2:17][NH:18][CH2:19]3)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 962WaterHCID 6331BoraneHCID 21070949tert-Butyl 4-(isoquinolin-5-yl)piperazine-1-carboxylate

生成物 1

HCID 210709471,1-Dimethylethyl 4-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1-piperazinecarboxylate収率 44%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

4-Isoquinoline-5-yl-piperazine-1-carboxylic acid tert-butyl ester (1.5 g) from Step 2 was dissolved in 5 mL of tetrahydrofuran (THF), and excess borane (BH3) in THF was added thereto. The mixture was brought to reflux for 1 hour, and allowed to cool to room temperature. The mixture was then further cooled in an ice bath, and water was carefully added to the reaction mix to consume excess borane. The reaction mix was then diluted with EtOAc, washed with saturated aqueous sodium bicarbonate (NaHCO3), dried over MgSO4, and chromatographed to provide 4-(1,2,3,4-tetrahydroisoquinolin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester as a viscous oil (0.668 g).

後処理

  1. temperatureto reflux for 1 hour
  2. temperatureThe mixture was then further cooled in an ice bath
  3. additionmix
  4. customto consume excess borane
  5. additionThe reaction mix
  6. additionwas then diluted with EtOAc
  7. washwashed with saturated aqueous sodium bicarbonate (NaHCO3)
  8. dry with materialdried over MgSO4
  9. customchromatographed

出典と根拠

ORDレコード
ord-088f496a429b4e08a3dc00dd593b586d
出典データセット
uspto-grants-2007_03
特許番号
US07196088B2

反応ノート

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