Benzyl Bromide → Ethanone, 1-[3-methyl-4-(phenylmethoxy)phenyl]-

HRID 460020

反応式

HRID 460020 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(#N)C>[CH2:18]([O:11][C:3]1[CH:4]=[CH:5][C:6]([C:8](=[O:9])[CH3:10])=[CH:7][C:2]=1[CH3:1])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 701354'-Hydroxy-3'-methylacetophenone

生成物 1

HCID 12969325Ethanone, 1-[3-methyl-4-(phenylmethoxy)phenyl]-

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
40 °C

実験手順

A mixture of 4-hydroxy-3-methylacetophenone (5.0 g) in dry acetonitrile (50 ml) was treated with potassium carbonate (5.06 g) and benzyl bromide (3.96 ml) and the reaction mixture heated at 40° C. After 3 hours the reaction was allowed to cool and was concentrated. The residue was partitioned between water and ethyl acetate; the aqueous layer separated and extracted twice more with ethyl acetate. The organic solutions were combined and were dried with brine and over magnesium sulfate and concentrated to give the title compound as a colourless oil

後処理

  1. temperatureto cool
  2. concentrationwas concentrated
  3. customThe residue was partitioned between water and ethyl acetate
  4. customthe aqueous layer separated
  5. extractionextracted twice more with ethyl acetate
  6. dry with materialwere dried with brine and over magnesium sulfate
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-da235d1cfd0447f28bdf62d1f7e867b5
出典データセット
uspto-grants-2007_03
特許番号
US07196107B2

関連ノート

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