Sodium Hydroxide → [4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetic acid

HRID 460026ノート

反応式

HRID 460026 の反応式
C([O:3][C:4](=[O:22])[CH2:5][C:6]1[S:10][C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[N:8][C:7]=1[CH3:21])C.[OH-].[Na+]>CO>[CH3:21][C:7]1[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=2)[S:10][C:6]=1[CH2:5][C:4]([OH:22])=[O:3]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 17972170Ethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}acetate2 回

生成物 1

HCID 17972178[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To ethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}acetate (intermediate 13, 0.5 g) in methanol (5 ml) was added 2M sodium hydroxide solution (3 ml). The resulting suspension was stirred at room temperature for 40 minutes, before the solvent was removed in vacuo. The residue was diluted with water (5 ml) acidified (2M hydrochloric acid) and the product extracted twice with ethyl acetate. The combined organic extracts were dried (magnesium sulfate), filtered and evaporated to give the title compound as a yellow solid.

後処理

  1. customwas removed in vacuo
  2. additionThe residue was diluted with water (5 ml)
  3. extractionthe product extracted twice with ethyl acetate
  4. dry with materialThe combined organic extracts were dried (magnesium sulfate)
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-ae2ceac6b2e347b3bf9e54495ec1ae92
出典データセット
uspto-grants-2007_03
特許番号
US07196107B2

反応ノート

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