Borohydride → 4-Methoxy-3-(4-methoxyphenyl)benzyl alcohol

HRID 460136

反応式

HRID 460136 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[O:10])=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[BH4-]>CO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 28123BorohydrideHCID 223911916,4'-Dimethoxybiphenyl-3-carbaldehyde

生成物 1

HCID 688416394-Methoxy-3-(4-methoxyphenyl)benzyl alcohol収率 87.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 4-methoxy-3-(4-methoxyphenyl)benzenecarboxaldehyde (1 g, 4.13 mmol) in methanol (12 mL) was treated with polymer-supported borohydride (10.3 mmol) and the mixture shaken for 16 hours. The resin was then filtered and the filtrate concentrated under reduced pressure to afford 0.88 g of title compound.

後処理

  1. filtrationThe resin was then filtered
  2. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a9f128eb66ba4a03a994df7c3c66eb4c
出典データセット
uspto-grants-2007_03
特許番号
US07196102B2

関連ノート

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