反応式
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)=[CH:7][C:6]([CH2:17][NH:18][CH:19](C2C=NC=CC=2)[CH3:20])=[CH:5][CH:4]=1.[N:27]1[CH:32]=[CH:31][C:30](C(N)C)=[CH:29][CH:28]=1.COC1C(C2C=CC(OC)=CC=2)=CC(C=O)=CC=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>>[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)=[CH:7][C:6]([CH2:17][NH:18][CH:19]([C:30]2[CH:31]=[CH:32][N:27]=[CH:28][CH:29]=2)[CH3:20])=[CH:5][CH:4]=1参加物
5
反応物 4
生成物 1
実験手順
The title compound was prepared by the same procedure for preparing (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-3-yl-ethyl)-amine from 1-Pyridin-4-yl-ethylamine (245 mg, 2 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (121 mg, 0.5 mmol) and sodium triacetoxyborohydride (212 mg, 1.0 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 51% yield (89 mg, 0.26 mmol).
後処理
- customThe title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 51% yield (89 mg, 0.26 mmol)
出典と根拠
- ORDレコード
- ord-d4d5ce6d479a4279a77e8d29ae5fc15b
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07196102B2
関連ノート
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