Ammonia → 1-(1-Methyl-1H-indol-4-yl)ethan-1-amine

HRID 460152ノート

反応式

HRID 460152 の反応式
[N:1]1C=CC=C(C(N)C)C=1.[CH3:10][N:11]1[C:19]2[C:14](=[C:15]([C:20](=O)[CH3:21])[CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12]1.N.CO.C([BH3-])#N.[Na+]>C(O)(=O)C>[CH3:10][N:11]1[C:19]2[C:14](=[C:15]([CH:20]([NH2:1])[CH3:21])[CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12]1

参加物

7

反応物 5

HCID 222AmmoniaHCID 887MethanolHCID 27716881-(Pyridin-3-yl)ethan-1-amineHCID 5003444Sodium cyanoborohydrideHCID 149872881-(1-Methyl-1H-indol-4-yl)ethanone

生成物 1

HCID 208032231-(1-Methyl-1H-indol-4-yl)ethan-1-amine収率 48%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

The title compound was prepared by the same procedure for preparing 1-pyridin-3-yl-ethylamine from 1-(1-methyl-1H-indol-4-yl)-ethanone (1.75 g, 10 mmol), 2 M ammonia solution in methyl alcohol (25 mL, 50 mmol, Aldrich), acetic acid (15 mL, J. T. Baker) and sodium cyanoborohydride (2.5 g, 40 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, 2 M ammonia solution in methyl alcohol/ethyl acetate 1/10) in form as light yellow oil in 48% yield (0.83 g, 4.8 mmol).

後処理

  1. customThe title compound was purified by column chromatography (silica gel, 2 M ammonia solution in methyl alcohol/ethyl acetate 1/10) in form as light yellow oil in 48% yield (0.83 g, 4.8 mmol)

出典と根拠

ORDレコード
ord-69d63a88b7634aa5ad6c0add816cb250
出典データセット
uspto-grants-2007_03
特許番号
US07196102B2

反応ノート

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