Hydrochloric Acid → 2-(2-Methoxyphenyl)-1,3-thiazole-4-carboxylic acid
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[S:10][CH:11]=[C:12]([C:14]([O:16]CC)=[O:15])[N:13]=1.[OH-].[Na+].Cl>CCO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[S:10][CH:11]=[C:12]([C:14]([OH:16])=[O:15])[N:13]=1参加物
5
実験手順
To a stirred solution of ethyl 2-(2-methoxy-phenyl)thiazole-4-carboxylate (0.27 g, 1.03 mmol) in EtOH (10 mL) was added 1N NaOH (aq) (5 mL). The resulting mixture was heated to reflux for 2 h. The mixture was cooled to RT, acidified with 1N HCl (aq) and concentrated by rotary evaporation. The residue was extracted with CH2Cl2 (3×15 mL). The extracts were combined, dried over MgSO4, filtered and concentrated by rotary evaporation to afford the title compound as an off-white solid. EI-MS m/z 236 (M+H).
後処理
- temperatureThe resulting mixture was heated
- temperatureto reflux for 2 h
- concentrationconcentrated by rotary evaporation
- extractionThe residue was extracted with CH2Cl2 (3×15 mL)
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated by rotary evaporation
出典と根拠
- ORDレコード
- ord-ef70904d91a04535ab151a5902302ed4
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07196104B2
反応ノート
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