Trifluoromethanesulfonic acid → 5-Methanesulfonyl-3,3-dimethyl-2,3-dihydro-benzofuran
反応式
[CH3:1][C:2]1([CH3:11])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1.F[C:13](F)(F)[S:14](O)(=[O:16])=[O:15].CS(OS(C)(=O)=O)(=O)=O>>[CH3:13][S:14]([C:8]1[CH:9]=[CH:10][C:5]2[O:4][CH2:3][C:2]([CH3:11])([CH3:1])[C:6]=2[CH:7]=1)(=[O:16])=[O:15]参加物
反応条件
- 温度
- 135 °C
実験手順
A mixture of 3,3-dimethyl-2,3-dihydro-benzofuran (example 14c) (870 mg, 5.87 mmol), trifluoromethanesulfonic acid (0.1 mL, 1.17 mmol) and methanesulfonic anhydride (2.04 g, 11.74 mmol) was heated to 135° C. After reaching this temperature, the heater was removed and the mixture was cooled down to room temperature. The mixture was poured into a solution of ice-water. The aqueous layer was extracted twice with ethyl acetate and the organic combined extract was washed with water, an aqueous solution of sodium bicarbonate, brine, dried (MgSO4), filtered, and evaporated. The residue was chromatographed on silica gel (30% to 50% ethyl acetate in hexane) to afford 317 mg of 5-Methanesulfonyl-3,3-dimethyl-2,3-dihydro-benzofuran. 24% yield. 1H-NMR (300 MHz, CDCl3): 1.39 (s, 6H), 3.04 (s, 3H), 4.36 (s, 2H), 6.90 (d, J=8.2 Hz, 1H), 7.67 (d, J=2.1 Hz, 1H), 7.74 (dd, J1=8.5 Hz, J2=2.1 Hz, 1H).
後処理
- customthe heater was removed
- temperaturethe mixture was cooled down to room temperature
- additionThe mixture was poured into a solution of ice-water
- extractionThe aqueous layer was extracted twice with ethyl acetate
- extractionthe organic combined extract
- washwas washed with water
- dry with materialan aqueous solution of sodium bicarbonate, brine, dried (MgSO4)
- filtrationfiltered
- customevaporated
- customThe residue was chromatographed on silica gel (30% to 50% ethyl acetate in hexane)
出典と根拠
- ORDレコード
- ord-8307b2abfb8c4e739c66c8a9f79813a8
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07196108B2
反応ノート
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