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Water → 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Methyl 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylate | HCID 619692 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylic Acid | HCID 10752341 | — |
反応手順
The mixture consisting of 500 mg of methyl 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylate, 160 mg of lithium hydroxide, 2 ml of water, 2 ml of THF and 2 ml of methanol is stirred at RT for 3 days. After dilution with 15 ml of water, unhydrolyzed ester is removed by extraction with ethyl acetate. The aqueous phase is adjusted to pH 5 using hydrochloric acid and stirred, and the precipitated solid is filtered off with suction and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07196114B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-2c96ff4f637f4338b0e2cb3a6cd9e194 |
| 出典メモ | uspto-grants-2007_03 |