反应详情

The mixture consisting of 500 mg of methyl 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylate, 160 mg of lithium hydroxide, 2 ml of water, 2 ml of THF and 2 ml of methanol is stirred at RT for 3 days. After dilution with 15 ml of water, unhydrolyzed ester is removed by extraction with ethyl acetate. The aqueous phase is adjusted to pH 5 using hydrochloric acid and stirred, and the precipitated solid is filtered off with suction and dried.

1. customAfter dilution with 15 ml of water, unhydrolyzed ester is removed by extraction with ethyl acetate
2. stirringstirred
3. filtrationthe precipitated solid is filtered off with suction
4. customdried