1,1-Dibromoethane → HCID 178497629、化合物

HRID 460434

反応式

HRID 460434 の反応式
[Zn:1].[Br:2]C(Br)C.[CH3:6][O:7][C:8](=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15]Br>C1COCC1>[Br-:2].[C:8]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][Zn+:1])([O:7][CH3:6])=[O:17]

参加物

5

反応物 3

HCID 112011,1-DibromoethaneHCID 23994ZincHCID 2734813Methyl 2-(bromomethyl)benzoate

生成物 1

HCID 178497629HCID 178497629、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
60 °C

実験手順

Under atmosphere of argon, to a solution of zinc powder (1.89 g) in anhydrous THF (15 ml) was added dibromoethane (116 μl) and the mixture was stirred for five minutes at 60° C. To the reaction mixture was added a solution of 2-bromomethylbenzoic acid methyl ester (4.42 g) in anhydrous THF (15 ml) over a period of 30 minutes at 0° C. and the mixture was stirred for 2 hours at the temperature to give a 2-carbomethoxybenzylzinc (II) bromide (benzyl zinc) solution.

後処理

  1. stirringthe mixture was stirred for 2 hours at the temperature

出典と根拠

ORDレコード
ord-6994cfd1917b4f6da990da2083b330a0
出典データセット
uspto-grants-2007_03
特許番号
US07196198B2

関連ノート

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