Benzenepropanoic acid → 3-(4-Iodophenyl)propanoic acid

HRID 460493ノート

反応式

HRID 460493 の反応式
[C:1]([OH:11])(=[O:10])[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[I:12](O)(=O)(=O)=O.S(=O)(=O)(O)O.II>O.C(O)(=O)C>[I:12][C:7]1[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][C:1]([OH:11])=[O:10])=[CH:9][CH:8]=1

参加物

7

反応物 4

HCID 107Benzenepropanoic acidHCID 807IodineHCID 1118Sulfuric AcidHCID 65185Metaperiodic acid

生成物 1

HCID 2332383-(4-Iodophenyl)propanoic acid収率 460.8%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒2 回

反応条件

温度
105 °C

実験手順

Hydrocinnamic acid is iodinated to form 4-iodohydrocinnamic acid. The process is performed by mixing 201.2 g hydrocinnamic acid, 1 L acetic acid, 152 mL water, 52.8 g periodic acid, 76 mL sulfuric acid, and 144 g iodine. The mixture is heated at 105° C. for 6.5 hours. Next, 200 mL water is added, and the mixture is cooled to room temperature overnight. The solid product in the resultant mixture is filtered and washed with water, yielding 350 g unpurified 4-iodohydrocinnamic acid. Further purification is not necessary and is not conducted, and the product is used as is in the second step.

後処理

  1. temperaturethe mixture is cooled to room temperature overnight
  2. filtrationThe solid product in the resultant mixture is filtered
  3. washwashed with water

出典と根拠

ORDレコード
ord-c4543b6f2743498eaf89c9a303be194c
出典データセット
uspto-grants-2007_03
特許番号
US07196214B2

反応ノート

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