2-Benzofurancarbonitrile, 4-methoxy- → 1-(Hydroxyimino)-1-(4-methoxybenzo(b)furan-2-yl)methylamine
反応式
[CH3:1][O:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]#[N:13])[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.Cl.[NH2:15][OH:16].C(=O)([O-])O.[Na+]>C(O)C>[OH:16][N:15]=[C:12]([NH2:13])[C:9]1[O:8][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:11]=2[CH:10]=1参加物
5
実験手順
To a solution (40 ml) of 4-methoxybenzo(b)furan-2-carbonitrile (2.8 g) in ethanol were added hydroxylamine hydrochloride (1.2 g) and sodium hydrogencarbonate (3.0 g). The mixture was refluxed under heating for 1.5 hr. The inorganic material was filtered off and the reaction mixture was concentrated under reduced pressure to give the title compound (3.4 g) as brown crystals.
後処理
- temperatureThe mixture was refluxed
- temperatureunder heating for 1.5 hr
- filtrationThe inorganic material was filtered off
- concentrationthe reaction mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-db3723df7251483195991df12b590345
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07196199B2
反応ノート
読み込み中…