Methanol → Methyl 4-Iodophenylacetate

HRID 460687

反応式

HRID 460687 の反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.S(Cl)(Cl)=O.[CH3:16]O>>[CH3:16][O:10][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([I:1])=[CH:7][CH:6]=1

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 1372144-Iodophenylacetic acid

生成物 1

HCID 10378700Methyl 4-Iodophenylacetate収率 86%

実験手順

A solution of 5 g (19 mmol) of (4-iodo-phenyl)-acetic acid in 50 mL of methanol (MeOH) was added dropwise 3.5 mL (48 mmol) of thionyl chloride (SOCl2), and the resulting mixture was stirred at rt for 36 h, after which time analysis by thin layer chromatography (TLC) indicated product formation. The mixture was concentrated to give 4.5 g (86% yield) of (4-iodo-phenyl)-acetic acid methyl ester as a pale beige oil as indicated by 1H NMR.

後処理

  1. concentrationThe mixture was concentrated

出典と根拠

ORDレコード
ord-f16e90a916704da2b92052ea9948e23b
出典データセット
uspto-grants-2007_03
特許番号
US07196111B2

関連ノート

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