Dicyclohexylthiourea → 4-(2,4-Dichloro-5-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrobromide

HRID 460821

反応式

HRID 460821 の反応式
[CH:1]1([NH:7][C:8]([NH:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[S:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:17][CH2:18][C:19]([C:21]1[CH:26]=[C:25]([S:27](=[O:30])(=[O:29])[NH2:28])[C:24]([Cl:31])=[CH:23][C:22]=1[Cl:32])=[O:20]>C(OCC)(=O)C>[BrH:17].[Cl:32][C:22]1[CH:23]=[C:24]([Cl:31])[C:25]([S:27](=[O:30])(=[O:29])[NH2:28])=[CH:26][C:21]=1[C:19]1([OH:20])[CH2:18][S:9][C:8](=[N:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[N:10]1[CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 727200DicyclohexylthioureaHCID 227564292-Bromo-2',4'-dichloro-5'-sulfamoylacetophenone

生成物 1

HCID 213947644-(2,4-Dichloro-5-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrobromide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

2.4 g of 1,3-dicyclohexyl-thiourea were added to 3,5 g of 2-bromo-2',4'-dichloro-5'-sulfamoylacetophenone in 40 ml of ethyl acetate. The whole was allowed to stand overnight at 20° C, the crystals were filtered off and washed with ethyl acetate. M.p. 161°-163° C.

後処理

  1. filtrationthe crystals were filtered off
  2. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-208c8c3e928e44cca51f415e62697259
出典データセット
uspto-grants-1977_12
特許番号
US04061647

関連ノート

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