p-Toluenesulfonic acid → HCID 20367252、化合物

HRID 460916ノート

反応式

HRID 460916 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][NH:6][NH2:7].C([O:16][C:17](=O)[CH:18]=[C:19]([NH2:23])OCC)C.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)C>[NH2:23][C:19]1[NH:7][N:6]([CH2:5][C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[C:2]([F:12])([F:13])[F:1])[C:17](=[O:16])[CH:18]=1

参加物

5

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl esterHCID 20367279{[2-(Trifluoromethyl)phenyl]methyl}hydrazine

生成物 1

HCID 20367252HCID 20367252、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

46 g of 2-trifluoromethylbenzylhydrazine were added dropwise, under nitrogen, to a solution of 38.2 g of β-amino-β-ethoxyacrylic acid ethyl ester and 2 g of p-toluenesulphonic acid in 250 ml of ethanol. After stirring overnight, the solvent was distilled off in vacuo and the residue was recrystallized from ethanol. The product was the compound identified above. Melting point: 184°, 22 g (34%).

後処理

  1. distillationthe solvent was distilled off in vacuo
  2. customthe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-cb261811cccd43a5bcb681a1d4b56aa2
出典データセット
uspto-grants-1977_12
特許番号
US04061653

反応ノート

読み込み中…