Acetic Acid → HCID 20285752、化合物

HRID 460955ノート

反応式

HRID 460955 の反応式
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([Br:8])[C:6]=1[Br:7].C(O)(=O)C.[ClH:13].[CH2:14]=O>O>[Cl:13][CH2:1][C:2]1[S:3][C:4]([CH3:14])=[C:5]([Br:8])[C:6]=1[Br:7]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 128752643,4-Dibromo-2-methylthiophene

生成物 1

HCID 20285752HCID 20285752、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 11.7 g. of 2-methyl-3,4-dibromo-thiophene in 30 ml. of acetic acid was added to 60 ml of concentrated hydrochloric acid. After dropping in 4.1 g. of a 37% aqueous solution of formaldehyde the mixture was heated to 70° C. for one hour. The reaction mixture was cooled, diluted with water and extracted with ether. The combined organic phases were washed with water, sodium bicarbonate and water, dried over sodium sulfate, filtered and evaporated to give 2-chloromethyl-3,4-dibromo-5-methyl-thiophene.

後処理

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with ether
  3. washThe combined organic phases were washed with water, sodium bicarbonate and water
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-e7e2f814aff949aba834b8cecc7b7a5c
出典データセット
uspto-grants-1977_12
特許番号
US04061656

反応ノート

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