Ethanol → (2,4-Dimethylthiophen-3-yl)methanol

HRID 460978ノート

反応式

HRID 460978 の反応式
[BH4-].[Na+].[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH:9]=[O:10].C(O)C>O>[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH2:9][OH:10]

参加物

5

反応物 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 111477702,4-Dimethylthiophene-3-carbaldehyde

生成物 1

HCID 12875266(2,4-Dimethylthiophen-3-yl)methanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.68 G. (18 mmol) of sodium borohydride was added in three portions to a solution of 10.08 g. (72 mmol) of 2,4-dimethylthiophene-3-carboxaldehyde in 120 ml. of ethanol. After 15 min., the reaction mixture was poured into water, extracted with ether, dried and the solvent evaporated. The resulting residue was recrystallized from hexane to yield 2,4-dimethyl-3-hydroxymethylthiophene, m.p. 80°-81° C.

後処理

  1. extractionextracted with ether
  2. customdried
  3. customthe solvent evaporated
  4. customThe resulting residue was recrystallized from hexane

出典と根拠

ORDレコード
ord-789808508e4648deaddf676c40b55dd7
出典データセット
uspto-grants-1977_12
特許番号
US04061656

反応ノート

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