Thionyl Chloride → 1-(2-Chloroethyl)-4-benzamidopiperidine

HRID 461004ノート

反応式

HRID 461004 の反応式
O[CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5]1.S(Cl)([Cl:21])=O>C1C=CC=CC=1>[Cl:21][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 203151761-(2-Hydroxyethyl)-4-benzamidopiperidine

生成物 1

HCID 213952311-(2-Chloroethyl)-4-benzamidopiperidine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

1 Gram of 1-(2-hydroxyethyl)-4-benzamidopiperidine suspended in 2 milliliters of dry benzene was treated with 0.62 gram of thionyl chloride. The stirred mixture was refluxed for 3 hours., then cooled and filtered to give the title compound as a light grey solid. Crystallisation from ethanol-ether of this hydrochloride gave 0.8 grams (62%) of pale yellow needles, melting point 238.5° C.

後処理

  1. temperatureThe stirred mixture was refluxed for 3 hours
  2. temperature, then cooled
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-580ea0ec41dd4e928347c076d7ee6ae6
出典データセット
uspto-grants-1977_12
特許番号
US04061758

反応ノート

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