2'-Chloro-4'-nitrovaleranilide → N-(4-amino-2-chlorophenyl)pentanamide

HRID 461017

反応式

HRID 461017 の反応式
[Cl:1][C:2]1[CH:14]=[C:13]([N+:15]([O-])=O)[CH:12]=[CH:11][C:3]=1[NH:4][C:5](=[O:10])[CH2:6][CH2:7][CH2:8][CH3:9]>C(O)(=O)C.[Fe]>[NH2:15][C:13]1[CH:12]=[CH:11][C:3]([NH:4][C:5](=[O:10])[CH2:6][CH2:7][CH2:8][CH3:9])=[C:2]([Cl:1])[CH:14]=1

参加物

4

反応物 1

HCID 36282822'-Chloro-4'-nitrovaleranilide

生成物 1

HCID 4257591N-(4-amino-2-chlorophenyl)pentanamide

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 176Acetic Acid溶媒

実験手順

2'-Chloro-4'-nitrovaleranilide (13.0 g.) is dissolved in warm glacial acetic acid (100 ml.) and iron powder (14 g.) is added portionwise to maintain gentle boiling. The resulting reaction mixture is refluxed for 1/2 hour and filtered. The filtrate is evaporated under reduced pressure and the residue is triturated with water. The solid that forms is collected (11.5 g.) and recrystallized from cyclohexane to yield 7,5 g., m.p. 96.5°-99° C.

後処理

  1. temperatureto maintain gentle boiling
  2. customThe resulting reaction mixture
  3. temperatureis refluxed for 1/2 hour
  4. filtrationfiltered
  5. customThe filtrate is evaporated under reduced pressure
  6. customthe residue is triturated with water
  7. customThe solid that forms is collected (11.5 g.)
  8. customrecrystallized from cyclohexane
  9. customto yield 7,5 g

出典と根拠

ORDレコード
ord-98feae33d9c949e49a347a1a114f60ea
出典データセット
uspto-grants-1977_12
特許番号
US04061763

関連ノート

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