Bromo-4'-chloro-3'-sulfamoylacetophenone → 4-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

HRID 461114

反応式

HRID 461114 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH3:16][NH:17][C:18]([NH:20][CH:21]([CH3:23])[CH3:22])=[S:19]>CC(C)=O>[BrH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:19][C:18](=[N:20][CH:21]([CH3:23])[CH3:22])[N:17]2[CH3:16])=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

参加物

4

反応物 2

HCID 12952390Bromo-4'-chloro-3'-sulfamoylacetophenoneHCID 142299001-Methyl-3-isopropylthiourea

生成物 1

HCID 227604664-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

6.1 g of 2-bromo-4'-chloro-3'-sulfamoylacetophenone were heated with 2.4 g of 1-methyl-3-isopropylthiourea in 50 ml of acetone for 10 minutes to 40° C, the separating oil was triturated to form crystals and the crystalline suspension was stirred for 1 hour at room temperature. Colorless solid body: melting point: 195° C (decomposition).

後処理

  1. customthe separating oil was triturated
  2. customto form crystals

出典と根拠

ORDレコード
ord-32104b1699e44898ad55d752a12d86bc
出典データセット
uspto-grants-1977_12
特許番号
US04061761

関連ノート

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