Thionyl Chloride → 4-Isopropyl-3-sulfamoylbenzoylchloride
反応式
[CH:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8](O)=[O:9])=[CH:6][C:5]=1[S:13](=[O:16])(=[O:15])[NH2:14])([CH3:3])[CH3:2].S(Cl)([Cl:19])=O>>[CH:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([Cl:19])=[O:9])=[CH:6][C:5]=1[S:13](=[O:16])(=[O:15])[NH2:14])([CH3:3])[CH3:2]参加物
3
実験手順
5 g of 4-isopropyl-3-sulfamoylbenzoic acid were boiled under reflux in 50 ml of thionylchloride until completely dissolved and the reaction mixture was then concentrated to 25 ml under reduced pressure. After allowing to dwell over night at 0° C, the crystals were filtered off over a sinter glass frit and washed with petroleum ether. Colorless body, melting point: 177° C.
後処理
- dissolutionuntil completely dissolved
- concentrationthe reaction mixture was then concentrated to 25 ml under reduced pressure
- waitto dwell over night at 0° C
- filtrationthe crystals were filtered off over a sinter glass frit
- washwashed with petroleum ether
出典と根拠
- ORDレコード
- ord-214e4131f8ad4597b2e7c479c445e79f
- 出典データセット
- uspto-grants-1977_12
- 特許番号
- US04061761
反応ノート
読み込み中…