Hydrochloric Acid → 2-Acetamido-2,3-dimethylbutanoic acid
反応式
[NH2:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[C:3]([OH:5])=[O:4].[C:10](OC(=O)C)(=[O:12])[CH3:11].Cl>[OH-].[Na+]>[C:10]([NH:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[C:3]([OH:5])=[O:4])(=[O:12])[CH3:11]参加物
5
実験手順
To a stirred solution of 2-amino-2,3-dimethylbutyric acid (13.1 g) in 55 ml 2N NaOH maintained at 5° C is added simultaneously dropwise but separately 17 ml acetic anhydride and 95 ml 2N NaOH so that the pH of the solution is maintained at about 8.5. After stirring at room temperature for a further 1/2 hour, the mixture is acidified with concentrated HCl and the product, (±)-2-acetylamino-2,3-dimethylbutyric acid, removed by filtration, washed with cold water and air-dried. A sample recrystallized from acetonitrile had melting point 189°-190° C.
後処理
- additionis added simultaneously dropwise
- customthe product, (±)-2-acetylamino-2,3-dimethylbutyric acid, removed by filtration
- washwashed with cold water
- customair-dried
- customA sample recrystallized from acetonitrile
出典と根拠
- ORDレコード
- ord-76b7dfbb330e4112b967c0a27b76dcf4
- 出典データセット
- uspto-grants-1977_12
- 特許番号
- US04062671
反応ノート
読み込み中…