7,8-Dichloroisoquinoline--hydrogen chloride (1/1) → Isoquinoline, 7,8-dichloro-1,2,3,4-tetrahydro-

HRID 461476ノート

反応式

HRID 461476 の反応式
Cl.[Cl:2][C:3]1[C:12]([Cl:13])=[C:11]2[C:6]([CH:7]=[CH:8][N:9]=[CH:10]2)=[CH:5][CH:4]=1>[Pt](=O)=O.CO>[Cl:2][C:3]1[C:12]([Cl:13])=[C:11]2[C:6]([CH2:7][CH2:8][NH:9][CH2:10]2)=[CH:5][CH:4]=1

参加物

4

反応物 1

HCID 125950637,8-Dichloroisoquinoline--hydrogen chloride (1/1)

生成物 1

HCID 123920Isoquinoline, 7,8-dichloro-1,2,3,4-tetrahydro-

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

The above prepared 7,8-dichloroisoquinoline hydrochloride was reduced in two portions by hydrogenation at 50-60 psi using 0.7 g. of platinum dioxide in 100 cc. of methanol, for one hour at ambient temperature. The mixture was filtered and concentrated. The residue was converted to the base using ammonium hydroxide and was extracted into ether. The extract was dried with magnesium sulfate, filtered and concentrated to give, as the residue, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. extractionwas extracted into ether
  4. dry with materialThe extract was dried with magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-82d9fabeaf3d4c0083a05f890fb1ee67
出典データセット
uspto-grants-1977_12
特許番号
US04062961

反応ノート

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