8-Chloroisoquinoline hydrochloride → 8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

HRID 461481ノート

反応式

HRID 461481 の反応式
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2>[Pt](=O)=O.CO>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][NH:10][CH2:9][CH2:8]2

参加物

4

反応物 1

HCID 123717488-Chloroisoquinoline hydrochloride

生成物 1

HCID 125950728-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

A solution of 11.0 g. of 8-chloroisoquinoline hydrochloride in 100 ml. of methanol was hydrogenated at atmospheric pressure over 0.5 g. of platinum dioxide as in Example 9. The mixture was filtered and concentrated to small volume. Ether was added, the mixture was filtered, and the solid recrystallized from ethanol to give 8-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride, m.p. 236°-238.5° C.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated to small volume
  3. additionEther was added
  4. filtrationthe mixture was filtered
  5. customthe solid recrystallized from ethanol

出典と根拠

ORDレコード
ord-67733e16e1d044a9b6756f68a15e3c7b
出典データセット
uspto-grants-1977_12
特許番号
US04062961

反応ノート

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