Dimethyl Sulfoxide → 7,8-Dichloro-1-methylisoquinoline

HRID 461501ノート

反応式

HRID 461501 の反応式
[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.[H-].[Na+].O.[CH3:16]S(C)=O>>[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[CH3:16])=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 679Dimethyl Sulfoxide2 回HCID 962Water2 回HCID 24758Sodium hydrideHCID 125950627,8-Dichloroisoquinoline

生成物 1

HCID 213938347,8-Dichloro-1-methylisoquinoline

反応条件

温度
70 °C

実験手順

Alternatively, 7,8-dichloro-1-methylisoquinoline is prepared by the following procedure. 7,8-Dichloroisoquinoline (0.019 mole) in 100 ml. of dimethylsulfoxide is added to a solution of sodium hydride (0.11 mole) in 100 ml of dimethylsulfoxide at 70° C. The reaction mixture is stirred at 70° C. for four hours under a nitrogen atmosphere. The reaction mixture is cooled, 100 ml. of water is added, and the mixture is poured into 1500 ml. of water. The aqueous mixture is extracted with benzene. The extract is washed, dried over sodium sulfate and evaporated to give 7,8-dichloro-1-methylisoquinoline.

後処理

  1. customAlternatively, 7,8-dichloro-1-methylisoquinoline is prepared by the following procedure
  2. temperatureThe reaction mixture is cooled
  3. additionthe mixture is poured into 1500 ml
  4. extractionThe aqueous mixture is extracted with benzene
  5. washThe extract is washed
  6. dry with materialdried over sodium sulfate
  7. customevaporated

出典と根拠

ORDレコード
ord-53383e55b9544eaba84b3df80e117137
出典データセット
uspto-grants-1977_12
特許番号
US04062961

反応ノート

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