Phosgene → (2,4-Dioxoimidazolidin-1-yl)carbamyl chloride

HRID 461534

反応式

HRID 461534 の反応式
[NH2:1][N:2]1[CH2:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[C:9](Cl)([Cl:11])=[O:10]>O1CCCC1>[Cl:11][C:9]([NH:1][N:2]1[CH2:6][C:5](=[O:7])[NH:4][C:3]1=[O:8])=[O:10]

参加物

4

反応物 2

HCID 6371PhosgeneHCID 728231-Aminohydantoin

生成物 1

HCID 20325743(2,4-Dioxoimidazolidin-1-yl)carbamyl chloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

11.5 g. (0.1 mol.) of 1-amino-2,4-dioxoimidazolidine are thoroughly stirred into 150 ml. of absolute tetrahydrofuran. A solution of 15 g. (0.15 mol.) of phosgene in 25 ml. of absolute tetrahydrofuran is added dropwise at 0°-5° over 20 minutes. The mixture is then stirred for 3 hours at room temperature. An almost clear solution results. This is filtered and the solvent is evaporated in vacuum. The oily residue crystallizes on trituration with petroleum ether to obtain 1-(chlorocarbonylamino)-2,4-dioxoimidazolidine, yield 17.2 g., m.p. 126° (dec.).

後処理

  1. customAn almost clear solution results
  2. filtrationThis is filtered
  3. customthe solvent is evaporated in vacuum
  4. customThe oily residue crystallizes on trituration with petroleum ether

出典と根拠

ORDレコード
ord-c4cc6d670166462285eaefd03e7c900b
出典データセット
uspto-grants-1977_12
特許番号
US04063019

関連ノート

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