3-(Dimethylamino)-8-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole → 3-(Dimethylamino)-8-hydroxymethyl-1,2,3,4-tetrahydrocarbazole

HRID 461553ノート

反応式

HRID 461553 の反応式
[CH3:1][N:2]([CH3:21])[CH:3]1[CH2:15][C:14]2[C:13]3[C:8](=[C:9]([C:16](OCC)=[O:17])[CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH2:5][CH2:4]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][N:2]([CH3:21])[CH:3]1[CH2:15][C:14]2[C:13]3[C:8](=[C:9]([CH2:16][OH:17])[CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH2:5][CH2:4]1

参加物

4

反応物 2

HCID 128917873-(Dimethylamino)-8-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazoleHCID 21226445Aluminium lithium hydride

生成物 1

HCID 128918683-(Dimethylamino)-8-hydroxymethyl-1,2,3,4-tetrahydrocarbazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Following a procedure similar to that described in Example 55 and using 2.4 g. of 3-(dimethylamino)-8-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole (Example 44), 1.6 g. of lithium aluminum hydride and 150 ml. of dry tetrahydrofuran there was obtained, after successive recrystallizations from isopropyl alcohol and ethyl alcohol, 0.56 g. of 3-(dimethylamino)-8-hydroxymethyl-1,2,3,4-tetrahydrocarbazole, m.p. 227°-230° C.

後処理

  1. customafter successive recrystallizations from isopropyl alcohol and ethyl alcohol, 0.56 g

出典と根拠

ORDレコード
ord-5e7da5a588b944ce8f2103536f0bdd03
出典データセット
uspto-grants-1977_12
特許番号
US04062864

反応ノート

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