Tetrahydrofuran → 2-(Bicyclo[2.2.1]hept-7-yl)ethylamine

HRID 461988ノート

反応式

HRID 461988 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].O1CCCC1.[CH:12]12[CH:18]([CH2:19][C:20]([NH2:22])=O)[CH:15]([CH2:16][CH2:17]1)[CH2:14][CH2:13]2>O>[CH:15]12[CH:18]([CH2:19][CH2:20][NH2:22])[CH:12]([CH2:17][CH2:16]1)[CH2:13][CH2:14]2

参加物

5

反応物 3

HCID 8028Tetrahydrofuran2 回HCID 21226445Aluminium lithium hydride2 回HCID 57053985Bicyclo[2.2.1]hept-7-yl acetamide

生成物 1

HCID 213919412-(Bicyclo[2.2.1]hept-7-yl)ethylamine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.0425 Mole of lithium aluminum hydride is dissolved in 100 ml. of anhydrous tetrahydrofuran at 0° C, under nitrogen, and then 0.0425 mole of bicyclo[2.2.1]hept-7-yl acetamide in 100 ml. of anhydrous tetrahydrofuran is added dropwise. The mixture is stirred for about 12 hours at room temperature and then about 10 ml. of water is carefully added to decompose excess lithium aluminum hydride (and complex). The mixture is then filtered and the filtrate then dried with potassium hydroxide pellets; filtered and the filtrate distilled, to remove solvent, affording 2-(bicyclo[2.2.1]hept-7-yl)ethylamine.

後処理

  1. customat 0° C
  2. filtrationThe mixture is then filtered
  3. dry with materialthe filtrate then dried with potassium hydroxide pellets
  4. filtrationfiltered
  5. distillationthe filtrate distilled
  6. customto remove solvent

出典と根拠

ORDレコード
ord-b6774ea8d7b94674b29ebc7663e32a37
出典データセット
uspto-grants-1977_12
特許番号
US04064258

反応ノート

読み込み中…