Diethyl Ether → (4-Methylbicyclo[2.2.2]octan-1-yl)methanol

HRID 461990ノート

反応式

HRID 461990 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)C.[CH3:12][C:13]12[CH2:20][CH2:19][C:16]([C:21](O)=[O:22])([CH2:17][CH2:18]1)[CH2:15][CH2:14]2.O1CCCC1>O.C(OCC)(=O)C>[OH:22][CH2:21][C:16]12[CH2:17][CH2:18][C:13]([CH3:12])([CH2:20][CH2:19]1)[CH2:14][CH2:15]2

参加物

7

反応物 4

HCID 3283Diethyl EtherHCID 8028TetrahydrofuranHCID 1365444-Methylbicyclo[2.2.2]octane-1-carboxylic acidHCID 21226445Aluminium lithium hydride2 回

生成物 1

HCID 13227648(4-Methylbicyclo[2.2.2]octan-1-yl)methanol

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

0.0952 Mole of lithium aluminum hydride is dissolved in 200 ml. of anhydrous diethyl ether, under nitrogen, and cooled to 0° C. 0.0952 Mole of 4-methylbicyclo[2.2.2]oct-1-yl carboxylic acid in 100 ml. of tetrahydrofuran is added dropwise, then the mixture stirred for 30 minutes. Excess lithium aluminum hydride is decomposed by the cautious addition of ethyl acetate, followed by the careful addition of 10 ml. of water. The mixture is then filtered and the filtrate washed with ethyl ether, then dried over anhydrous magnesium sulfate and filtered. The solvent is then evaporated from the filtrate, under vacuum, affording 1-(hydroxymethyl)-4-methylbicyclo[2.2.2]octane.

後処理

  1. additionfollowed by the careful addition of 10 ml
  2. filtrationThe mixture is then filtered
  3. washthe filtrate washed with ethyl ether
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe solvent is then evaporated from the filtrate, under vacuum

出典と根拠

ORDレコード
ord-f0bf4585fc164ba4b2f62705de1a3733
出典データセット
uspto-grants-1977_12
特許番号
US04064258

反応ノート

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