Hydrochloric Acid → Glyphosate

HRID 462126ノート

反応式

HRID 462126 の反応式
Cl.[C:2]([CH2:5][NH:6][CH2:7][P:8](=[O:15])([O:12]CC)[O:9]CC)([OH:4])=[O:3]>>[P:8]([CH2:7][NH:6][CH2:5][C:2]([OH:4])=[O:3])([OH:15])([OH:12])=[O:9]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 12633685N-[(Diethoxyphosphoryl)methyl]glycine

生成物 1

HCID 3496Glyphosate収率 62.7%

実験手順

60 ml. of concentrated hydrochloric acid are added to 11.25 g. (0.05 moles) of diethyl N-carboxymethyl-aminomethyl-phosphonate, and the mixture is boiled for 2 hours. The reaction mixture is concentrated to one-fourth volume under a pressure of 80 to 100 mmHg., and the residue is triturated with 60 ml. of ethanol. The solid substance is filtered when cold, dissolved in 15 to 20 ml. of hot water, the solution is decolorized, cooled, and the product is precipitated with 45 ml. of acetone. 5.3-5.7 g. (62.7-67.5%) of N-phosphonomethyl-glycine are obtained.

後処理

  1. concentrationThe reaction mixture is concentrated to one-fourth volume under a pressure of 80 to 100 mmHg
  2. custom, and the residue is triturated with 60 ml
  3. filtrationThe solid substance is filtered when cold
  4. dissolutiondissolved in 15 to 20 ml
  5. temperaturecooled
  6. customthe product is precipitated with 45 ml

出典と根拠

ORDレコード
ord-538811341d8e4ab8b2112a7961410de4
出典データセット
uspto-grants-1977_12
特許番号
US04065491

反応ノート

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