1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 46217

反応式

HRID 46217 の反応式
[Br:1]Br.[OH:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][C:5]=1[C:14]([OH:16])=[O:15]>C(O)(=O)C>[Br:1][C:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4]([OH:3])=[C:5]([C:14]([OH:16])=[O:15])[CH:6]=1

参加物

4

反応物 2

HCID 68441-Hydroxy-2-naphthoic acid2 回HCID 24408Bromine

生成物 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acid収率 92.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Bromine (6.1 mL, 120 mmol) was added to a solution of 1-hydroxy-2-naphthoic acid (compound 66, 18.9 g, 100 mmol) in glacial acetic acid (250 mL). The mixture was stirred at room temperature overnight. The resulting solid was filtered and dried in vacuo to yield the title compound (24.6 g, 92%) as a white solid.

後処理

  1. filtrationThe resulting solid was filtered
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-50e18a4d23c74d9490e3660b81c779fe
出典データセット
uspto-grants-2013_09
特許番号
US08541380B2

関連ノート

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