Benzaldehyde → 3,5-Dibenzylidene-1-(2-phenylethyl)-4-piperidone monohydrochloride

HRID 462259

反応式

HRID 462259 の反応式
[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:16](=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[ClH:24]>C(O)C>[ClH:24].[CH:16](=[C:11]1[C:12](=[O:15])[C:13](=[CH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:14][N:9]([CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:10]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 96437N-Phenethyl-4-piperidinone

生成物 1

HCID 681188373,5-Dibenzylidene-1-(2-phenylethyl)-4-piperidone monohydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Twenty-five grams of 1-(2-phenylethyl)-4-piperidone and 38 g of benzaldehyde are reacted in 180 ml of ethanol in the presence of 40 ml of concentrated hydrochloric acid at reflux temperature for about 5 hours and left at room temperature for about 16 hours yielding 25.5 g of material, melting point 217°-220° C, dec. Crystallization from 50 ml of hot dimethylformamide and 100 ml of acetonitrile yields 22 g of the title compound, melting point 225°-227° C, dec.

後処理

  1. temperatureat reflux temperature for about 5 hours

出典と根拠

ORDレコード
ord-b0b857edc23e4ecdb0e73d1f4d1d7e60
出典データセット
uspto-grants-1977_12
特許番号
US04065617

関連ノート

読み込み中…