Hydrazinecarboxylic acid, ethyl ester → HCID 13424603、化合物

HRID 462412ノート

反応式

HRID 462412 の反応式
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([F:16])[CH:9]=2)=[CH:6][CH:7]=1.[C:17](OCC)(=[O:20])[NH:18][NH2:19]>C(O)CCC>[F:16][C:10]1[CH:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]3[N:3]([C:17](=[O:20])[NH:18][N:19]=3)[N:4]=2)[CH:13]=[CH:12][C:11]=1[O:14][CH3:15]

参加物

4

反応物 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 203982843-Chloro-6-(3-fluoro-4-methoxyphenyl)pyridazine

生成物 1

HCID 13424603HCID 13424603、化合物

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A mixture comprising 4.0 g. of 3-chloro-6-(3-fluoro-4-methoxyphenyl)-pyridazine (U.S. Pat. No. 4,092,311), 3.54 g. of ethyl carbazate and 100 ml. of butanol is stirred at reflux for 3 days and then cooled in an ice bath. The resulting solid is collected by filtration and dried, giving 2.4 g. of the desired product as a tan solid, m.p. 289°-290° C.

後処理

  1. temperatureat reflux for 3 days
  2. temperaturecooled in an ice bath
  3. filtrationThe resulting solid is collected by filtration
  4. customdried
  5. customgiving 2.4 g

出典と根拠

ORDレコード
ord-29a49613a3bc47d8bec0d2974de3a5f3
出典データセット
uspto-grants-1985_05
特許番号
US04515791

反応ノート

読み込み中…