Sodium amide → 4-Amino-3,5-dimethylbenzaldehyde
反応式
[NH2:1][C:2]1[C:14]([CH3:15])=[CH:13][C:5]([CH:6]([OH:12])CS(C)(=O)=O)=[CH:4][C:3]=1[CH3:16].[NH2-].[Na+]>CS(C)=O>[NH2:1][C:2]1[C:3]([CH3:16])=[CH:4][C:5]([CH:6]=[O:12])=[CH:13][C:14]=1[CH3:15]参加物
4
実験手順
A solution of 14.6 g. of 4-amino-3,5-dimethyl-α-[(methylsulfonyl)-methyl]-benzyl alcohol in 50 ml. of absolute dimethylsulfoxide was treated with 1.17 g. of sodium amide, stirred for 2 hours at room temperature, diluted with 500 ml. of water and extracted with two 500 ml. portions of ethyl acetate. The ethyl acetate extract was washed with two 200 ml. portions of water and evaporated under vacuum. After recrystallization of the residue from cyclohexane, there was obtained 4-amino-3,5-dimethyl-benzaldehyde having a melting point of 75°-76° C.
後処理
- additiondiluted with 500 ml
- extractionof water and extracted with two 500 ml
- extractionThe ethyl acetate extract
- washwas washed with two 200 ml
- customportions of water and evaporated under vacuum
- customAfter recrystallization of the residue from cyclohexane
出典と根拠
- ORDレコード
- ord-108e6ab545a343b5b07e1a58cbf918c3
- 出典データセット
- uspto-grants-1985_05
- 特許番号
- US04515948
反応ノート
読み込み中…