Pyrrolidine → 2-(Dimethoxymethyl)-6-hydroxy-2,5,7,8-tetramethyl-chroman-4-one

HRID 462581

反応式

HRID 462581 の反応式
[C:1]([C:4]1[C:9]([OH:10])=[C:8]([CH3:11])[C:7]([CH3:12])=[C:6]([OH:13])[C:5]=1[CH3:14])(=[O:3])[CH3:2].[CH3:15][O:16][CH:17]([O:21][CH3:22])[C:18](=O)[CH3:19].N1CCCC1>C1(C)C=CC=CC=1>[CH3:15][O:16][CH:17]([O:21][CH3:22])[C:18]1([CH3:19])[CH2:2][C:1](=[O:3])[C:4]2[C:9](=[C:8]([CH3:11])[C:7]([CH3:12])=[C:6]([OH:13])[C:5]=2[CH3:14])[O:10]1

参加物

5

反応物 3

HCID 31268PyrrolidineHCID 80650Pyruvic aldehyde dimethyl acetalHCID 10867205Ethanone, 1-(2,5-dihydroxy-3,4,6-trimethylphenyl)-

生成物 1

HCID 130515362-(Dimethoxymethyl)-6-hydroxy-2,5,7,8-tetramethyl-chroman-4-one収率 70%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

15.0 g (77 mmoles) of acetyl-trimethylhydroquinone, 10.5 g (89 mmoles) of 1,1-dimethoxy-propan-2-one and 9.30 g (131 mmoles) of pyrrolidine were reacted in toluene solution by a method similar to that of Example 1 to give the above product. Boiling point: 165°-170° C./6.10-5 mbar (bulb tube); yield: 70%.

後処理

  1. customto give the above product

出典と根拠

ORDレコード
ord-3acfebb68dd044ffb37b002faf72c46d
出典データセット
uspto-grants-1985_05
特許番号
US04515975

関連ノート

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