Triethylamine → HCID 13657356、化合物

HRID 4626ノート

反応式

HRID 4626 の反応式
C(N(CC)CC)C.[CH:8]1[CH:13]=[CH:12][C:11]([N:14]=[C:15](Cl)Cl)=[CH:10][CH:9]=1.[N:18]1([CH2:24][C:25]2[CH:26]=[C:27]([CH:37]=[CH:38][CH:39]=2)[O:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]([NH:35][NH2:36])=[O:34])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>C1COCC1>[C:11]1([NH:14][C:15]2[O:34][C:33]([NH:32][CH2:31][CH2:30][CH2:29][O:28][C:27]3[CH:37]=[CH:38][CH:39]=[C:25]([CH2:24][N:18]4[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]4)[CH:26]=3)=[N:35][N:36]=2)[CH:12]=[CH:13][CH:8]=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 12145Phenylimidocarbonyl chlorideHCID 13657330N-(3-{3-[(Piperidin-1-yl)methyl]phenoxy}propyl)hydrazinecarboxamide

生成物 1

HCID 13657356HCID 13657356、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1.4 ml (10 mmol) of triethylamine and 0.7 ml (5 mmol) of phenyl isocyanide dichloride are added to 1.5 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-hydrazine carboxamide in 30 ml of THF and the mixture is stirred at room temperature until the reaction is quantitative. Solid triethylammonium chloride is filtered off, the filtrate is concentrated by evaporation under vacuum, and the solid residue is recrystallised from ethanol. The analytical values are summarized in Table II.

後処理

  1. filtrationSolid triethylammonium chloride is filtered off
  2. concentrationthe filtrate is concentrated by evaporation under vacuum
  3. customthe solid residue is recrystallised from ethanol

出典と根拠

ORDレコード
ord-9220619335324543b39346a03e5120a5
出典データセット
uspto-grants-1988_02
特許番号
US04727081

反応ノート

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