Water → 2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid

HRID 462660

反応式

HRID 462660 の反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]([CH:21]([CH3:23])[CH3:22])[C:16]([O:18]CC)=[O:17].O>C(O)C>[Cl:3][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]([CH:21]([CH3:23])[CH3:22])[C:16]([OH:18])=[O:17]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 20283987Ethyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate

生成物 1

HCID 39476432-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid収率 90%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 0.60 grams of sodium hydroxide dissolved in 10 ml of ethanol was added 3.30 g of the above ester. The mixture was stirred at room temperature for 4 hours, after which water was added, and the mixture was washed with toluene. The organic phase was discarded. The product was acidified, extracted into ether, washed with water, dried and solvent removed to yield 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid, m.p. 132°-135°, in 90% yield.

後処理

  1. washthe mixture was washed with toluene
  2. extractionextracted into ether
  3. washwashed with water
  4. customdried
  5. customsolvent removed

出典と根拠

ORDレコード
ord-ae7e67b2425643fa8e174fc101f32af8
出典データセット
uspto-grants-1985_05
特許番号
US04517130

関連ノート

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