Hydrogen Bromide → HCID 13653512、化合物

HRID 462757ノート

反応式

HRID 462757 の反応式
[CH3:1][N:2]([N:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[C:19](=[O:27])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[F:26])[C:3](=[O:13])[CH2:4][NH:5]C(OC(C)(C)C)=O.[BrH:28]>CO>[BrH:28].[CH3:1][N:2]([N:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[C:19](=[O:27])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[F:26])[C:3](=[O:13])[CH2:4][NH2:5]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 13653510HCID 13653510、化合物

生成物 1

HCID 13653512HCID 13653512、化合物収率 95%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A slurry prepared from 1-[N-methyl-(t-butoxycarbonylamino)acetamido]-2-(2-fluorobenzoyl)pyrrole (20 g, 53.2 mmol) and 100 ml of methanol solution containing 12 ml of 48% HBr (0.106 mol) was stirred at room temperature for 6 hours. The resultant solution was evaporated to a solid which was recrystallized from isopropanol-ether to give 18 g (95%) of powder.

後処理

  1. customThe resultant solution was evaporated to a solid which
  2. customwas recrystallized from isopropanol-ether

出典と根拠

ORDレコード
ord-ed454a7998714da786b3ae86b76fdb3d
出典データセット
uspto-grants-1985_05
特許番号
US04517195

反応ノート

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